TABLE 3.
Main Results of Gynecological and Gastrointestinal Disorders Found in 196 Patients With LS Confirmed by Biopsy and Their 10-Fold Age-Matched Cohort
| Comorbidity | ICD-10 | Prevalence in 196 women and girls with LS, % (n) | Prevalence in 1,960 controls, % (n) | RR | 95% CI | p |
|---|---|---|---|---|---|---|
| Vulvar cancer | C51 | 7.1 (14) | 0.1 (2) | 70.0 | 32.7–149.8 | <0.001 |
| Cervical cancer | C53 | 0.5 (1) | 0.1 (2) | 5.0 | 0.6–43.3 | 0.14 |
| Endometrial cancer | C54 | 3.6 (7) | 0.9 (17) | 4.1 | 1.8–9.2 | 0.001 |
| Vulvar HSIL and/or dVIN | N90.1 N90.2 D07.1 | 3.6 (7) | 0.0 (0) | NA | NA | NA |
| Celiac disease | K90.0 | 2.0 (4) | 0.3 (6) | 6.7 | 2.2–19.9 | 0.001 |
| Urinary incontinence | N39.3 N39.4 R32 | 8.2 (16) | 1.6 (31) | 5.2 | 3.0–8.8 | <0.001 |
| Dyspareunia | N94.1 | 1.5 (3) | 0.1 (1) | 30.0 | 7.0–128.3 | <0.001 |
| Interstitial cystitis | N30.1 | 2.0 (4) | 0.3 (6) | 6.7 | 2.2–19.9 | 0.001 |