Figure 3.

The proportion of CD14⁺CD36^hiCD84^hi monocytes was correlated with disease progression. (A) UMAP plots showing CD14, CCR2, CD36, and CD84 expression in myeloid cells. Red triangles indicate CD14+ CCR2– cell subpopulations. (B) The proportion of CD14⁺ CD36^hi CD84^hi monocytes (cluster #6064 defined by the Citrus analysis in Figure 2C ) abundance in myeloid cell populations in individual samples and (C) the correlation with disease progression. *** p < 0.001. Information for disease with clinical progression is also shown. IPF, idiopathic pulmonary fibrosis; CTD-ILD, connective-tissue disease-related interstitial lung disease; AEx, acute exacerbation; SSc, systemic sclerosis; SjS, Sjogren syndrome; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; DM, dermatomyositis; MCTD, mixed connective tissue disease; na, not accessed.