Table 1.
Reactome top 20 deregulated pathways performed by g:Profiler web tool. The table reports the name of deregulated pathways with the relative p-value, the total number of involved genes for the specific pathway, and the involved number of genes in our analysis. The fifth column depicts the name of the specific genes dysregulated in the pathways
| Perturbated pathways | Adjusted p-value | Term size | Intersection size | Intersections |
|---|---|---|---|---|
| Metabolism | 9,63835E-13 | 2075 | 31 | GNG5, NPAS2,ACSS3,CEMIP,MT-ND2,PTGIS,PLD1,MVD,ABCA1,MT-CO2,MGLL,MT-ND1,HMGCS1,PARP9,MT-ATP8,MT-ND5,MT-ATP6,CH25H,VCAN,MT-CYB,HMOX1,B4GALNT1,SQLE,SRM,ACAT2,TNFAIP8L3,ME1,ENPP1,LUM,DCN,CYP1B1 |
| Metabolism of lipids | 1,82E-07 | 728 | 15 | NPAS2, ACSS3,PTGIS,PLD1,MVD,ABCA1,MGLL,HMGCS1,CH25H,B4GALNT1,SQLE,ACAT2,TNFAIP8L3,ME1,CYP1B1 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling | 4,50E-07 | 127 | 7 | MT-ND2, MT-CO2,MT-ND1,MT-ATP8,MT-ND5,MT-ATP6,MT-CYB |
| The citric acid (TCA) cycle and respiratory electron transport | 1,00074E-06 | 177 | 8 | MT-ND2,MT-CO2,MT-ND1,MT-ATP8,MT-ND5,MT-ATP6,MT-CYB,ME1 |
| Immune system | 1,00074E-06 | 2041 | 19 | HSPA1B,PAG1,C1S,MT2A,ATP6V0C,TUBA4A,PLD1,CRISPLD2,SOCS3,IFIT1,CFH,OAS2,HSPA1A,IL1R1,IFI30,FTH1,MMP1,HMOX1,C1ORF35 |
| Signal transduction | 3,79281E-06 | 2514 | 15 | GNG5,PDE5A,PAG1,ARHGAP22,ALDH1A3,ATP6V0C,GDNF,TUBA4A,DHRS3,PLD1,FGF1,EPSTI1,SOCS3,ABCA1,MGLL |
| Extracellular matrix organization | 6,11705E-06 | 298 | 9 | EFEMP1,MFAP1,SPP1,VCAN,MMP1,LUM,ADAMTS5,TGFB2,DCN |
| Cholesterol biosynthesis | 9,25359E-06 | 24 | 4 | MVD,HMGCS1,SQLE,ACAT2 |
| Metabolism of steroids | 3,23404E-05 | 148 | 6 | PTGIS,MVD,HMGCS1,CH25H,SQLE,ACAT2 |
| Respiratory electron transport | 5,7508E-05 | 103 | 5 | MT-ND2,MT-CO2,MT-ND1,MT-ND5,MT-CYB |
| Interferon gamma signaling | 7,76787E-05 | 87 | 5 | MT2A,SOCS3,OAS2,IFI30,MID1 |
| Cellular responses to stimuli | 0,000101278 | 765 | 8 | NPAS2,HSPA1B,MT2A,ATP6V0C,TUBA4A,MT-CO2,HMGA2,HSPA1A |
| Interferon Signaling | 0,000207149 | 193 | 6 | MT2A,SOCS3,IFIT1,OAS2,IFI30,MID1 |
| Signaling by nuclear receptors | 0,000207149 | 291 | 7 | GNG5,ALDH1A3,DHRS3,ABCA1,NRIP1,RARB,CXCL12 |
| Neuronal System | 0,000277254 | 400 | 5 | KCNC4,APBA1,GNG5,KCNN4,TUBA4A |
| Potassium Channels | 0,000298821 | 103 | 3 | KCNC4,GNG5,KCNN4 |
| Cellular responses to stress | 0,000669883 | 751 | 7 | NPAS2,HSPA1B,ATP6V0C,TUBA4A,MT-CO2,HMGA2,HSPA1A |
| Disease | 0,000780704 | 1639 | 15 | GNG5,TUBA4A,FGF1,ABCA1,HSPA1A,PARP9,IL1R1,VCAN,PLK2,HMOX1,LUM,FZD4,ADAMTS5,DCN,CYP1B1 |
| Neutrophil degranulation | 0,000897936 | 476 | 7 | HSPA1B,ATP6V0C,PLD1,CRISPLD2,HSPA1A,FTH1,C1ORF35 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 0,000897936 | 57 | 3 | HSPA1B,TUBA4A,HSPA1A |