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. 2023 Mar 20;91(4):303–315. doi: 10.1007/s00280-023-04521-y

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 5 — Emetine acted via blockade of multiple signaling cascades. MGC803 and HGC-27 cells were treated with different concentrations of emetine for 18 h, and then the proteins were extracted for western blot. A Western blot assay was used to verify the effects of emetine against Wnt/β-catenin signaling pathway. B Inhibitory effects of emetine on the downstream effector and target proteins of Hippo signaling pathway. C Regulation of emetine on the pivotal proteins of MAPKs and PI3K/AKT signaling axes