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. 2023 Mar 20;60:101075. doi: 10.1016/j.blre.2023.101075

Fig. 1.

Fig. 1

The influence of microbes on the coagulation system. Microbes and their secreted molecules can directly interact with platelets and clotting proteins (clotting factors and fibrinogen) to induce platelet activation, hypercoagulation, inflammation, anomalous clotting (amyloid containing clots and fibrinaloids), and subsequent endothelial damage. Herpes viruses, including EBV and cytomegalovirus, interact with platelets via toll-like and complement receptors. Created using Biorender.com.