Table 2.
Female | Male | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
ZT6 | ZT18 | ZT6 | ZT18 | Significant differences | ||||||
Gene | Sham | SCI | Sham | SCI | Sham | SCI | Sham | SCI | Main effect | Interactions |
Per1 | 1.00 ± 0.40 | 2.83 ± 0.88 | 0.85 ± 0.37 | 2.27 ± 0.56 | 1.35 ± 0.22 | 2.80 ± 0.43 | 1.02 ± 0.30 | 3.21 ± 0.76 | SCI | N.S. |
Clock | 1.00 ± 0.05 | 0.89 ± 0.08 | 0.63 ± .14 | 0.89 ± .10 | 1.19 ± .11 | 1.29 ± 0.19 | 0.56 ± 0.04 | 0.85 ± 0.12 | ZT | ZT6 × sex |
Mhc II | 1.00 ± 0.14 | 0.65 ± 0.09 | 0.97 ± .06 | 0.77 ± .10 | 1.07 ± 0.83 | 0.83 ± .08 | 0.91 ± 0.23 | 0.90 ± 0.24 | N.S. | N.S. |
IL-6 | 1.00 ± 0.26 | 1.28 ± 0.66 | 0.31 ± .08 | 0.35 ± .07 | 2.13 ± 0.64 | 0.36 ± .07 | 0.68 ± 0.23 | 0.69 ± 0.23 | ZT | N.S. |
G6pc | 1.00 ± 0.32 | 1.19 ± 0.25 | 1.70 ± .79 | 1.37 ± .25 | 4.46 ± 1.5 | 2.10 ± .95 | 0.67 ± 0.18 | 2.44 ± 0.29 | Sex | Sham ZT6 × sex |
Gck | 1.00 ± 0.12 | 1.19 ± 0.40 | 1.84 ± .37 | 1.13 ± .46 | 0.53 ± 0.11 | 0.87 ± .22 | 0.83 ± 0.16 | 0.74 ± 0.35 | Sex | N.S. |
Hnf1a | 1.00 ± 0.11 | 0.77 ± 0.14 | 0.83 ± .13 | 1.05 ± .16 | 0.97 ± 0.12 | 1.26 ± .18 | 0.72 ± 0.10 | 1.15 ± 0.12 | N.S. | N.S. |
Data only for genes not shown in figures. For statistical comparisons (far right column): “SCI” = significant main effect of SCI vs. sham; “ZT” = significant main effect of time (ZT6 vs. ZT18); “sex” = significant main effect of sex; “Sham x ZT” = significant interaction between sham and ZT.
dpi, days post-injury; SCI, spinal cord injury; N.S., no significant difference; ZT, Zeitgeber time.