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. 2019 May 28;36(12):1923–1934. doi: 10.1089/neu.2018.6101

Table 2.

Expression of additional Clock (Per1, Clock), Inflammatory (Mhc II, IL-6), and Glucose Metabolism (G6pc, Gck, Hnf1a) Genes at 2 dpi in the Liver

  Female Male  
  ZT6 ZT18 ZT6 ZT18 Significant differences
Gene Sham SCI Sham SCI Sham SCI Sham SCI Main effect Interactions
Per1 1.00 ± 0.40 2.83 ± 0.88 0.85 ± 0.37 2.27 ± 0.56 1.35 ± 0.22 2.80 ± 0.43 1.02 ± 0.30 3.21 ± 0.76 SCI N.S.
Clock 1.00 ± 0.05 0.89 ± 0.08 0.63 ± .14 0.89 ± .10 1.19 ± .11 1.29 ± 0.19 0.56 ± 0.04 0.85 ± 0.12 ZT ZT6 × sex
Mhc II 1.00 ± 0.14 0.65 ± 0.09 0.97 ± .06 0.77 ± .10 1.07 ± 0.83 0.83 ± .08 0.91 ± 0.23 0.90 ± 0.24 N.S. N.S.
IL-6 1.00 ± 0.26 1.28 ± 0.66 0.31 ± .08 0.35 ± .07 2.13 ± 0.64 0.36 ± .07 0.68 ± 0.23 0.69 ± 0.23 ZT N.S.
G6pc 1.00 ± 0.32 1.19 ± 0.25 1.70 ± .79 1.37 ± .25 4.46 ± 1.5 2.10 ± .95 0.67 ± 0.18 2.44 ± 0.29 Sex Sham ZT6 × sex
Gck 1.00 ± 0.12 1.19 ± 0.40 1.84 ± .37 1.13 ± .46 0.53 ± 0.11 0.87 ± .22 0.83 ± 0.16 0.74 ± 0.35 Sex N.S.
Hnf1a 1.00 ± 0.11 0.77 ± 0.14 0.83 ± .13 1.05 ± .16 0.97 ± 0.12 1.26 ± .18 0.72 ± 0.10 1.15 ± 0.12 N.S. N.S.

Data only for genes not shown in figures. For statistical comparisons (far right column): “SCI” = significant main effect of SCI vs. sham; “ZT” = significant main effect of time (ZT6 vs. ZT18); “sex” = significant main effect of sex; “Sham x ZT” = significant interaction between sham and ZT.

dpi, days post-injury; SCI, spinal cord injury; N.S., no significant difference; ZT, Zeitgeber time.