Table 4.
Other myeloid cell subpopulations in adipose tissue
| Myeloid cell type | Species | Gender | Depot | Subpopulation | Markers | Obesity correlation (−negative/+posotive) | Reference |
|---|---|---|---|---|---|---|---|
| Monocytes | mouse (C57BL/6J) | males | WAT (epididymal) | Mon1 | Fn1, Retnla | – | Jaitin et al.201 |
| Mon2 | Plac8, Clec4e | no correlation | |||||
| classical | Ccr2, Ly6c2 | no correlation | Cottam et al.61 | ||||
| non-classical | Ear2, Cx3cr1 | no correlation | |||||
| BAT (intrascapular) | monocytes Ly6clow | Treml4 | not reported | Silva et al.208 | |||
| monocytes Ly6cint | Plac8 | not reported | |||||
| monocytes Ly6chi | Ly6c2 | not reported | |||||
| human | women | WAT (subcutaneous) | ncMos | FCGR3A, HES4 | – | Weinstock et al.204 | |
| Mo-1 | FCER1A | + | |||||
| Mo-2 | CSF3R, FCAR, SELL | + | |||||
| Dendritic cells | mouse (C57BL/6J) | males | WAT (epididymal) | cDC1 | Clec9a, Xcr1 | + | Cottam et al.61 |
| activated cDC1 | Clec9a, Xcr2, Ccr7 | + | |||||
| cycling cDC1 | Clec9a, Xcr1, Pclaf, Stmn 1 | no correlation | |||||
| cDC2 | Sirpa, Cd209 | − | |||||
| activated cDC2 | Sirpa, Cd210, Ccr7 | + | |||||
| cycling cDC2 | Sirpa, Cd209, Pclaf, Stmn 1 | no correlation | |||||
| moDCs | Ear2 | − | |||||
| human | women | WAT (subcutaneous) | cDC1 | IRF8, DPP4, CADM1, XCR1 | + | Weinstock et al.204 | |
| cDC2A | CD1C, IRF4, IL7R, LAMP3 | + | |||||
| cDC2B | CD1C, IRF4, FCER1A, CLEC10A | + |
Subpopulations of adipose tissue monocytes and dendritic cells across white and brown adipose depots in mice and humans, defined by the expression of specific marker genes. Their association with obesity, wherever reported, is depicted as + (positive correlation), − (negative correlation), −− (strong negative correlation), or ‘‘no correlation.’’ Mon1/2 and Mo1/2, monocyte subpopulations; ncMos, non-canonical monocytes; cDCs, conventional dendritic cells.201