In 2021, the U.S. age-adjusted drug overdose death rate was 32.4 per 100,000 population. The highest rates were in West Virginia (90.9) and the District of Columbia (63.6); the lowest rates were in the Upper Midwest and Texas. The lowest state rates were those in Nebraska (11.4), South Dakota (12.6), and Iowa (15.3).
Source: National Center for Health Statistics, National Vital Statistics System, Mortality Data. https://www.cdc.gov/nchs/nvss/deaths.htm
For more information on this topic, CDC recommends the following link: https://www.cdc.gov/drugoverdose/index.html
Footnotes
Deaths per 100,000 standard population. Age-adjusted drug overdose death rates were calculated using the direct method and the 2000 U.S. Census Bureau standard population. In 2021, the age-adjusted drug overdose death rate was 32.4 per 100,000 standard population.
Drug overdose deaths were identified using International Classification of Diseases, Tenth Revision underlying cause-of-death codes X40–X44, X60–X64, X85, and Y10–Y14.