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. Author manuscript; available in PMC: 2023 Mar 20.
Published in final edited form as: Cancer Metastasis Rev. 2023 Feb 21;42(1):99–112. doi: 10.1007/s10555-023-10094-2

Fig 1: The metastatic cascade.

Fig 1:

Tumor cells leave the primary site of the tumor and intravasate into the neighboring vasculature followed by extravasation and eventual seeding at a secondary site. Several factors (extrinsic and intrinsic) regulate this process. The interaction between the tumor cell and its surrounding ECM at the primary site, vasculature, and secondary site primarily governs all the steps of this cascade.