Skip to main content
. Author manuscript; available in PMC: 2023 Mar 20.
Published in final edited form as: Cancer Metastasis Rev. 2023 Feb 21;42(1):99–112. doi: 10.1007/s10555-023-10094-2

Fig 2: Tumor mass dormancy and Single-cell dormancy.

Fig 2:

Dormancy can imply one of the two situations shown here. Tumor cell dormancy is when there is a balance between cell proliferation and cell death such that the net change is zero. Factors governing tumor mass dormancy include an impaired angiogenic response (angiogenic dormancy) and a heightened cytotoxic immune response (immune-mediated dormancy). Single-cell dormancy on the other hand is marked by an arrest in proliferation and is a state of “hibernation” that the tumor cell adapts and escapes chemotherapeutic drugs and immunosurveillance. This is governed by several extrinsic and intrinsic factors. These include factors such as TGFβ2, WNT5a, several Laminins and Collagens.