TABLE 1.
HLA allele association with active TB
| No. participants with allele | No. participants lacking allele | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| HLA allele a | HLA allele frequency (%) | Active TB | QFT+ & QFT‐ | Active TB | QFT+ & QFT‐ | Odds ratio | P‐value b | Corrected p‐value | Population coverage (%) |
| DQA1*03:01 | 7.1 | 24 | 21 | 75 | 516 | 7.9 | 8.0 E‐10 | 6.9 E‐08 | 26.4 |
| DPB1*04:02 | 10.3 | 25 | 40 | 74 | 495 | 4.2 | 2.0 E‐06 | 1.7 E‐04 | 19.2 |
| DRB4*01:01 | 27.0 | 42 | 127 | 57 | 401 | 2.3 | 0.0003 | 0.03 | 47.4 c |
| DPB1*105:01 | 25.6 | 12 | 150 | 87 | 385 | 0.4 | 0.0006 | 0.05 | 0.1 d |
| A*23:17 | 6.8 | 0 | 43 | 99 | 494 | 0.0 | 0.0008 | >0.05 | 0.0 e |
| DQA1*01:05 | 5.3 | 0 | 34 | 99 | 503 | 0.0 | 0.006 | >0.05 | 2.3 |
| DRB1*11:01 | 12.9 | 21 | 61 | 78 | 474 | 2.1 | 0.01 | >0.05 | 10.5 |
| DQA1*03:03 | 21.7 | 13 | 125 | 86 | 412 | 0.5 | 0.02 | >0.05 | 6.9 |
| B*15:03 | 9.9 | 16 | 47 | 83 | 489 | 2.0 | 0.03 | >0.05 | 1.3 |
| DQB1*02:01 | 15.4 | 8 | 90 | 90 | 447 | 0.4 | 0.03 | >0.05 | 23.0 |
| DRB1*03:01 | 17.5 | 10 | 101 | 89 | 434 | 0.5 | 0.04 | >0.05 | 17.8 |
| DRB1*07:01 | 17.8 | 25 | 88 | 74 | 447 | 1.7 | 0.04 | >0.05 | 18.2 |
a
When no result was obtained for a particular locus those participants were excluded from the calculations, the total number of participants for each allele does therefore not add up to 636, or ATB (n = 99), and QFT ± (n = 537, where QFT + (n = 334), and QFT − (n = 203)).
b
Bonferroni corrected threshold for a significant p‐value = 0.0006.
c
Coverage based in linkage with DR4, 7, and 9 alleles.
d
Rare worldwide, but 25.4% in South African Black and 20% in Brazilian Black.
e
Rare worldwide, but 7.7% in South African Black and 8% in Brazilian Black.