Relationship between various Ca2+ signaling parameters and the wave initiation parameter. Dependence of the relative active time (A), interoscillation interval variability (B), activation delay (C), correlation-based network node degree (D), wave-network node degree (E), and average node weight in the wave network (F) on the initiation parameter for stimulation protocols with 8 mM glucose (first and third row, cyan) and 12 mM glucose (second and fourth row, blue). Gray dots represent values of individual cells, and boxplots show the lowest 1/6, the intermediate 2/3, and the highest 1/6 connected cells in the correlation network. All panels show the pooled data from all recordings whereby individual values were normalized by the average value of the specific parameter in the given islet. Box charts are defined as in Fig. 3. Boxes determine the interval between the 25th and the 75th percentile, whiskers denote the 10th and the 90th percentile, and lines within the boxes indicate the median. Data were pooled from the following number of islets/cells: 8/865 (8 mM glc); 8/1103 (12 mM glc). Statistical significance: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001; n.s., not significant. Effect sizes: negligible – N (δ < 0.147), small – S (0.33 > δ ≥ 0.147), medium – M (0.474 > δ ≥ 0.33), or large – L (δ ≥ 0.474). To see this figure in color, go online.