Figure 5.
Characterizing the overlap of specific β cell subpopulations. (A) Correlation-based functional β cell network extracted from a typical islet. Node size reflects the number of functional connections per cell. The red-colored cells indicate 1/6 of the 1) most connected cells, i.e., hub cells (upper left), 2) wave initiators, i.e., cells with the highest initiation parameter values (upper right), 3) first responding cells to stimulatory glucose concentrations, i.e., cells with the lowest activation delays (lower left), and 4) most active cells, i.e., cells with the highest active times (lower right). (B) Bar plots show the relative overlap of specific cell subpopulations compared with the overlap by chance that two cells belong to the same sets of subpopulations (zero means an approximately 2.8%, i.e., (1/6)2, overlap). To see this figure in color, go online.