Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary depictions of the four modes of necroptosis execution. Each mode is distinguished by differences in sensitivity to initial protein levels (orange text; see Fig. 5), rate constants (not depicted; see Fig. 6), and mechanism of RIP1 ubiquitination regulation by CYLD and A20. Promotion of complex II formation (and hence necroptosis) by CYLD or A20 is represented by arrows (green or blue); inhibition is represented by a red line with a bar.
