Figure 5.

Sensitivity analyses and model-predicted protein targets for each mode of execution. (A) Changes in TTD for “representative” parameter sets of each mode (see materials and methods). Black shaded regions signify decreases in initial protein concentrations; white shaded regions signify increases. (B) Knockdown (KD) (70%) and overexpression (OE) (10-fold) of potential targets identified in (A) for all parameter sets for each mode. The number of parameter sets that do not result in cell death (n_∞) are included to the right. Solid black lines, medians; dashed black lines, means; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 (Mood’s median test).