Figure 2.

Cumulative incidence curves for developing contralateral breast cancer in the presence of competing risk of death for any cause

(A–E) Cumulative incidence for carriers (blue line) and non-carriers (red line) of combined protein-truncating variants (PTVs) and pathogenic/likely pathogenic missense variants (MSVs) in BRCA1 (A), combined PTVs and pathogenic/likely MSVs in BRCA2 (B), PTVs in CHEK2 (C), PTVs in PALB2 (D), and combined PTVs and pathogenic/likely pathogenic MSVs in TP53 (E). PTVs and pathogenic/likely pathogenic MSVs as defined in Dorling et al.¹⁸ were considered. We limited the y axis to the range (0.00, 0.30) to better visualize the curves. The x axis is restricted to 15 years from diagnosis because of the low number of carriers after 15 years.