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. 2023 Feb 10;110(3):460–474. doi: 10.1016/j.ajhg.2023.01.009

Figure 4.

Figure 4

Representative immunostaining of H2A.Z in normal myometrium, MED12-mutated UL, and ULs with germline mutations in ACTL6A, DMAP1, and YEATS4

Normal myometrium and UL with somatic MED12 c.131G>A (GenBank: NM_005120.3) (p.Gly44Asp) mutation were used as positive controls. Neoplastic cells of ACTL6A-, YEATS4-, and DMAP1-mutated ULs show negative or very weak (My6105, My6606) to moderate (My6564, My6589 My6621, My6638, My6660) H2A.Z staining but have preserved staining in capillary wall and isolated positive lymphocytes. The intensity of immunoreaction in parentheses: 0 = negative/weak; 1 = moderate; 2 = strong. The scores for all stained sections are presented in Table S5. The scale bars show 20 μm.