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. 2023 Mar 20;14:1388. doi: 10.1038/s41467-023-37083-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c Monoclonal anti-DNase1L3 antibodies and their germline (GL) variants were titrated against DNase1L3 (a), dsDNA (b) and cardiolipin (c). Curves on the graph correspond to the fitted four-parameter logistic (4PL) model used to calculate the EC₅₀. d, e Comparison of the EC₅₀ for antibody binding to DNase1L3 (yellow), dsDNA (green), and cardiolipin (pink) using mutated (75G12, 75A11, 627A11 and 88F7) and GL reverted (75G12/A11_GL, 627A11_GL and 88F7_GL) monoclonal antibodies. Antibodies 75G12 and 75A11 are the same antibody when reverted to GL. Bars show the mean EC₅₀ and the error bars represent upper and lower EC₅₀ values.