TABLE 2.

Change in pH, Na+, and K+ from baseline to end-of-study.

	Primary study		Placebo control study
pH	Δ	p	Δ	p
Intramuscular	0.13 ± 0.04	<0.05	−0.24 ± 0.09	0.08
Serum	0.04 ± 0.01	<0.05	0.02 ± 0.01	0.22
[Na+]	Δ, mM	p	Δ, mM	p
Intramuscular	−1 ± 1	0.42	10 ± 1	<0.05
Serum	14 ± 5	<0.05	−3 ± 1	0.06
[K+]	Δ, mM	p	Δ, mM	p
Intramuscular	−0.32 ± 0.11	<0.05	−0.37 ± 0.07	<0.05
Serum	−0.01 ± 0.13	0.92	−0.11 ± 0.12	0.42

Values are expressed as means ± SE. n = 9 primary study, n = 4 placebo control study. P for univariate t-test for the change within a study.