Table 3.

Main effects of time and cannabis use frequency and their interaction for each clinical outcome.

Outcome	Effect	Cohen's D Mean; 95% CI	Post. p-value
HADS [Anxiety]	Main effect of time	−0.11; −0.24–0.03	p = 0.111
	Main effect of cannabis use	−0.07; −0.18–0.00	p = 0.301
	Time x cannabis use interaction	0.08; 0.00–0.24	p = 0.338
HADS [Depression]	Main effect of time	–0.14; –0.26- –0.01	p = 0.030
	Main effect of cannabis use	0.00; 0.00–0.00	p = 0.990
	Time x cannabis use interaction	0.00; 0.00 to 0.00	p = 0.990
AIS	Main effect of time	−0.11; −0.26–0.04	p = 0.149
	Main effect of cannabis use	−0.08; −0.23–0.00	p = 0.454
	Time x cannabis use interaction	0.00; 0.00–0.02	p = 0.530
BPI [Severity]	Main effect of time	0.00; −0.08–0.08	p = 0.952
	Main effect of cannabis use	0.07; 0.02-0.12	p = 0.006
	Time x cannabis use interaction	0.00; −0.03–0.02	p = 0.951
CUD symptoms	Main effect of time	0.07; −0.35–0.50	p = 0.733
	Main effect of cannabis use	0.55; 0.31-0.86	p < 0.001
	Time x cannabis use interaction	0.04; −0.21–0.27	p = 0.736

HADS, Hospital Anxiety and Depression Scale; AIS, Athens Insomnia Scale; BPI, Brief Pain Inventory; CUD, Cannabis Use Disorder. Bolded p-values indicate a statistically significant effect.