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. 2023 Jan 5;50(5):1466–1486. doi: 10.1007/s00259-022-06089-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Normal body distribution of PSMA-ligands. [⁶⁸ Ga]Ga-PSMA-11, [⁶⁸ Ga]Ga-PSMA-I&T, [¹⁸F]F-DCFPyL, and [¹⁸F]F-rhPSMA-7.3 applications lead to notable kidney uptake. Bladder retention is high for [⁶⁸ Ga]Ga-PSMA-11, [⁶⁸ Ga]Ga-PSMA-I&T, and [¹⁸F]F-DCFPyL and lower for [¹⁸F]F-rhPSMA-7.3. Reference organs for ligands with kidney-dominant excretion are liver and parotid gland. [¹⁸F]F-PSMA-1007 leads to high liver uptake due to hepatic excretion. Reference organs for ligands with liver excretion are spleen and parotid gland. Focal uptake in the pelvic bone is noted on the [¹⁸F]F-rhPSMA-7.3 PET corresponding to metastatic disease. [⁶⁸ Ga]Ga-PSMA-I&T subpart was modified with permission from [130]