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. 2023 Jan 5;50(5):1466–1486. doi: 10.1007/s00259-022-06089-w

Table 3.

PSMA-ligands for PET/CT imaging

Characteristic [68 Ga]Ga-PSMA-11 [68 Ga]Ga-PSMA-I&T [18F]F-DCFPyL [18F]F-PSMA-1007 [18F]F-rhPSMA-7.3
Binding motif Urea-based Urea-based Urea-based Urea-based Urea-based
Half-life 68 min 68 min 110 min 110 min 110 min
Dominant excretion route Kidney Kidney Kidney Liver Kidney
Published 2012 [15] 2015 [18, 94] 2011 [14], 2015 [19] 2016 [20] 2020 [21]
Status Extensive retrospective data; completed phase 2/3; Approved* Extensive retrospective data Extensive retrospective data; completed phase 2/3; Approved* Extensive retrospective data; completed phase 2/3; Approved* Extensive retrospective data; under phase 3 investigation (NCT04186819 and NCT04186845)

Characteristics and current status. *Refers to regulatory approval for clinical use and distribution on a national or international level