Fig. 2.

¹⁸F-Florzolotau PET images of patients with progressive supranuclear palsy. The images illustrate ¹⁸F-Florzolotau uptake in the HC group (panel A), entire patient cohort (panel B), as well as in the PSP-RS (panel C) and PSP-non-RS (panel D) groups. Compared with the HC group, patients with PSP showed significantly increased binding mainly in the pallido-nigro-luysian axis (panel E). While the patterns of tracer accumulation were similar in the two patient groups, the binding intensity was markedly lower in patients with PSP-non-RS (panel F). The color bars in panels A − D indicate SUVR values, whereas the color bar in panels E–F denote threshold values from the voxel-wise comparisons. Abbreviations: HC, healthy control; PSP, progressive supranuclear palsy; PSP-RS, progressive supranuclear palsy-Richardson’s syndrome; PSP-non-RS, other PSP subtypes expect progressive supranuclear palsy-Richardson’s syndrome; SUVR, standardized uptake value ratio