Fig. 4.

Regional vulnerability and ¹⁸F-Florzolotau PET staging system for patients with progressive supranuclear palsy. Frequencies of positive regions (panel A) and associated conditional probabilities (panel B) in the entire study cohort. Criteria for determining the ¹⁸F-Florzolotau pathology staging system (panel C) and the ¹⁸F-Florzolotau modified staging system (panel E). Disease severity was characterized with the PSP rating scale (PSPrs) and analyzed according to disease stages (panel D and F). Abbreviations: PSP, progressive supranuclear palsy; FR, frontal cortex; PA, parietal cortex; TE, temporal cortex; OC, occipital cortex; PU, putamen; GP, globus pallidus; TH, thalamus; STN, substantia nucleus; RN, red nucleus; SN, substantia nigra; Ra, raphe nuclei; LC, locus coeruleus; DE, dentate; CEWM, cerebellar white matter; -, negative; + , mildly positive; ++ , moderately positive; + + + , strongly positive