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. 2023 Mar 20;13:4583. doi: 10.1038/s41598-023-31484-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MDM2 inhibitors, nutlin-3a and navtemadlin, inhibit the growth of p53 wildtype (p53^WT) cancer cell lines cultured in hypoxia (1% O₂). (a–c) Concentration-growth curves of three p53 wildtype cell lines (human HCT116 p53^+/+, human MCF7, and mouse B16-F10 p53^+/+) in normoxic and hypoxic conditions. (d–f) Concentration-growth curves of three p53 knockout and mutant cell lines (human HCT116 p53^−/−, human HT-29 p53^mut, and mouse B16-F10 p53^−/−) in normoxic and hypoxic conditions. Cell growth (as assessed by percent confluence normalised to untreated wells) was measured after 72 h of treatment with MDM2 inhibitors. Each data point represents the averaged value of triplicates from one independent experiment (n = three independent experiments). The line indicates the best fit model for concentration-growth response.