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. 2023 Mar 7;14:1146234. doi: 10.3389/fpls.2023.1146234

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Copyright © 2023 Margolin, Schäfer, Allen, Gers, Woodward, Sutherland, Blumenthal, Meyers, Shaw, Preiser, Strasser, Crispin, Williamson, Rybicki and Chapman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunogenicity of spike trimers in hamsters when produced in plants and mammalian cells. (A) Immunization schematic depicting the timing of immunizations and sampling during the experiment. (B) Neutralizing antibody titres (ID₅₀) against the matched wildtype (Wuhan) viral isolate. (C) Neutralizing antibody titres (ID₅₀) against heterologous Delta virus. Pre-bleed= day -2, first bleed = day 14, final bleed = day 46.