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Network diagram of different treatment options for mHSPC (A–F). AAP, abiraterone acetate and prednisone; ADT, androgen deprivation treatment; APA, apalutamide; DARO, darolutamide; DOC, docetaxel; ENZA, enzalutamide; HVD, high volume disease; LVD, low volume disease; OS, overall survival; PFS, progression free survival; RT, radiotherapy; The connector line “_” represents combination of different treatment regimens.
