TABLE 2.
Results of univariate SNP-based heritability estimates using LD-score regression of predicted probability of suicidal behaviour (SB), psychiatric disorders and education in years and income.
| Phenotype/Reference | Ancestry | # of SNPs | SNP-based heritability (SE) | z-score | p | Mean χ2 | λ GC | Intercept (SE)a |
|---|---|---|---|---|---|---|---|---|
| Suicidal behaviour (SB) | ||||||||
| Suicidal ideation | ||||||||
| Recent thoughts of suicide or self-harm | EUR | 9,561,902 | 0.0143 (0.0038) | 3.76 | 8.50 × 10−5 | 1.0402 | 1.0426 | 1.0067 (0.0064) |
| Thought life not worth living (TLNWL) | EUR | 1,096,648 | 0.0735 (0.0054) | 13.61 | 1.74 × 10−42 | 1.1788 | 1.1578 | 1.0087 (0.0072) |
| Thoughts of death | EUR | 13,559,508 | 0.0246 (0.0071) | 3.46 | 0.0003 | 1.0314 | 1.0309 | 1.0012 (0.0065) |
| Ever contemplated self-harm (ECSH) | EUR | 11,386,518 | 0.0427 (0.0051) | 8.38 | 2.65 × 10−17 | 1.1190 | 1.1093 | 1.0206 (0.0068) |
| Suicidal attempt | ||||||||
| Attempted suicide (SA) | EUR | 11,601,089 | 0.0799 (0.0123) | 6.49 | 4.29 × 10−11 | 1.1107 | 1.0988 | 1.0225 (0.0092) |
| Ever attempted suicide | EUR | 10,941,854 | 0.1461 (0.0892) | 1.64 | 0.0505 | 1.0085 | 1.0061 | 0.9946 (0.0062) |
| Completed suicide | ||||||||
| Completed suicide (Otsuka et al., 2019) | EA | 8,381,404 | 0.0776 (0.0303) | 2.56 | 0.0052 | 1.0756 | 1.0741 | 1.0514 (0.0075) |
| Self-harm | ||||||||
| Ever self-harmed (ESH) | EUR | 12,075,154 | 0.0217 (0.0044) | 4.93 | 4.11 × 10−7 | 1.0613 | 1.0536 | 1.0107 (0.0066) |
| SH needing hospital treatment | EUR | 10,169,094 | 0.0129 (0.0038) | 3.39 | 0.0004 | 1.0364 | 1.0410 | 1.0065 (0.0062) |
| Psychiatric disorders | ||||||||
| Schizophrenia (Pardinas et al., 2018) | EUR | 1,153,380 | 0.4100 (0.0138) | 29.71 | 2.85 × 10−194 | 1.9325 | 1.6822 | 1.0702 (0.0113) |
| Schizophrenia (Lam et al., 2019) | EA | 10,694,924 | 0.3784 (0.0222) | 17.05 | 1.75 × 10−65 | 1.3100 | 1.2464 | 1.0002 (0.0096) |
| Bipolar Disorder (Stahl et al., 2019) | EUR | 1,184,385 | 0.3872 (0.0190) | 20.39 | 1.03 × 10−92 | 1.3670 | 1.3061 | 1.0189 (0.0081) |
| MDD (Wray et al., 2018) | EUR | 1,081,131 | 0.0774 (0.0047) | 15.74 | 9.29 × 10−55 | 1.2659 | 1.2365 | 0.9954 (0.0092) |
| MDD (Giankopolou et al., 2021) | EA | 7,440,942 | 0.0080 (0.0022) | 3.64 | 0.0001 | 1.0419 | 1.0345 | 1.0093 (0.0065) |
| Anorexia nervosa (Duncan et al., 2017) | EUR | 10,120,601 | 0.2403 (0.0382) | 6.29 | 1.59 × 10−10 | 1.0793 | 1.0772 | 1.0089 (0.0095) |
| PTSD (Duncan et al., 2018) | EUR | 13,206,098 | 0.0464 (0.0205) | 2.26 | 0.0112 | 1.0127 | 1.0165 | 0.9939 (0.0059) |
| ADHD (Demontis et al., 2018) | EUR | 8,047,421 | 0.2268 (0.0145) | 15.64 | 1.94 × 10−55 | 1.2966 | 1.2531 | 1.0336 (0.0102) |
| Alcohol use disorder (Walters et al., 2018) | EUR | 9,271,144 | 0.0952 (0.0199) | 4.78 | 8.76 × 10−7 | 1.0601 | 1.0588 | 1.0182 (0.0063) |
| Insomnia (Jansen et al., 2019) | EUR | 1,117,678 | 0.0456 (0.0019) | 24.00 | 1.39 × 10−127 | 1.3617 | 1.3061 | 1.0140 (0.0078) |
| Behavioural traits | ||||||||
| Drinks per week (Liu et al., 2019) | EUR | 11,916,706 | 0.0485 (0.0021) | 23.09 | 2.92 × 10−118 | 1.4472 | 1.3169 | 0.9267 (0.0084) |
| Drinks per week (Matoba et al., 2020) | EA | 5,961,480 | 0.0731 (0.0420) | 1.740 | 0.0819 | 1.0892 | 1.0225 | 1.0009 (0.0080) |
| Cigarettes per day (Liu et al., 2019) | EUR | 12,003,613 | 0.0724 (0.0068) | 10.65 | 8.72 × 10−27 | 1.3301 | 1.2201 | 0.9595 (0.0095) |
| Cigarettes per day (Matoba et al., 2019) | EA | 5,925,778 | 0.0669 (0.0116) | 5.76 | 4.46 × 10−9 | 1.1059 | 1.0957 | 1.0096 (0.0088) |
| Smoking (ever vs never) Kanai et al., 2019 | EA | 13,531,752 | 0.0290 (0.0042) | 6.90 | 2.60 × 10−12 | 1.1092 | 1.0975 | 1.0024 (0.0081) |
| Anthropometric traits | ||||||||
| Body mass index (Locke et al., 2015) | EUR | 2,554,637 | 0.1297 (0.0056) | 23.16 | 5.76 × 10−119 | 1.2603 | 1.0772 | 0.6729 (0.0079) |
| Body mass index (Sakau & Kanai et al., 2021) | EA | 13,236,464 | 0.1772 (0.0078) | 22.72 | 1.42 × 10−114 | 1.6636 | 1.4926 | 1.0740 (0.0188) |
| Socioeconomic-related traits | ||||||||
| Income (Hill et al., 2016) | EUR | 1,217,311 | 0.0599 (0.0056) | 10.70 | 5.09 × 10−27 | 1.1613 | 1.1428 | 1.0290 (0.0071) |
| Education years (Okbay et al., 2016) | EUR | 8,146,840 | 0.1108 (0.0037) | 29.95 | 2.19 × 10−197 | 1.6445 | 1.4745 | 0.9377 (0.0092) |