TABLE 1.
Univariate predictors of early trial termination or early trial termination due to poor accrual
| Trial characteristic | Proportion of trials terminated early (n = 8687) | p‐Value | Proportion of trials terminated early due to accrual issues among all terminated trials (n = 1975) | p‐Value |
|---|---|---|---|---|
| Cancer category | ||||
| Hematologic cancer | 23.8% | 0.011 | 35.5% | 0.78 |
| Solid tumor | 22.9% | 33.8% | ||
| CNS tumor | 21.5% | 36.4% | ||
| Multiple | 17.1% | 37.7% | ||
| Therapeutic intent | ||||
| Anticancer | 22.8% | 0.86 | 33.6% | <0.001 |
| Supportive care | 22.3% | 52.4% | ||
| Intervention category | ||||
| Drug/biologic | 22.4% | 0.24 | 32.3% | <0.001 |
| Radiation | 25.2% | 53.7% | ||
| Procedure | 22.7% | 38.1% | ||
| Behavioral | 13.6% | 25.0% | ||
| Device | 28.2% | 45.5% | ||
| Multiple | 24.2% | 43.8% | ||
| Bone marrow/stem cell transplant or other cell therapy | 27.2% | 38.4% | ||
| Other | 24.8% | 64.0% | ||
| Design | ||||
| Randomized | 21.2% | 0.563 | 35.6% | 0.012 |
| Non‐randomized | 20.4% | 27.5% | ||
| Sex | ||||
| Male & female | 23.0% | 0.32 | 33.5% | 0.041 |
| Male | 20.9% | 43.0% | ||
| Female | 21.3% | 39.8% | ||
| Age category | ||||
| Adult | 23.1% | 0.016 | 33.8% | 0.024 |
| Pediatric | 13.5% | 60.0% | ||
| Adult & pediatric | 19.2% | 43.2% | ||
| Geriatrics | ||||
| Geriatric | 22.7% | 0.558 | 34.6% | 0.836 |
| Not geriatric | 25.0% | 30.8% | ||
| Phase | ||||
| 1 | 21.2% | <0.001 | 28.6% | <0.001 |
| 2 | 25.4% | 41.0% | ||
| 3 | 18.5% | 26.8% | ||
| 4 | 25.6% | 47.8% | ||
| Funding source | ||||
| Industry | 20.1% | <0.001 | 15.7% | <0.001 |
| Government | 20.9% | 32.6% | ||
| Other | 27.1% | 46.7% | ||
| Multiple | 23.2% | 42.8% | ||
| Start date | ||||
| 2007–2009 | 23.8% | 0.209 | 36.3 | 0.056 |
| 2010–2012 | 22.7% | 36.2 | ||
| 2013–2015 | 21.8% | 30.7 | ||
| Start year | ||||
| 2007 | 21.8% | 0.385 | 40.9 | 0.130 |
| 2008 | 25.5% | 37.9 | ||
| 2009 | 22.7% | 33.6 | ||
| 2010 | 23.4% | 39.3 | ||
| 2011 | 23.4% | 34.7 | ||
| 2012 | 21.2% | 34.1 | ||
| 2013 | 21.4% | 35.1 | ||
| 2014 | 22.0% | 27.6 | ||
| 2015 | 22.2% | 29.0 | ||
| Location | ||||
| USA | 24.4% | <0.001 | 37.6% | <0.001 |
| USA & International | 16.8% | 18.6% | ||