TABLE 3.

Evidence of peripheral 5-HT level in CUMS-induced depressive-like behavior animal model.

Animals	Drug	Duration of treatment	5-HT level change after CUMS	5-HT level change after treatment	References
Male SPF C57BL/6 mice	Fluoxetine	28 days	Decreased.	Increased.	[(Chen et al., 2021a)]
Male SPF Wistar rats	Taurine	28 days	Decreased.	Increased.	[(Wu et al., 2017)]
Male C57BL/6 mice	Fluoxetine	42 days	No changed.	Increased.	[(Cheng et al., 2021)]
Male athymic nude mice (NCr-nu)	Fluoxetine	21 days	Decreased.	Increased.	[(Zhang et al., 2020)]
Female C57BL/6 mice	Fluoxetine	14 days	Decreased.	Increased.	[(Yang et al., 2021)]
Male CD-1 mice	Sesame	42 days	Decreased.	Increased.	[(Zhao et al., 2019)]
Male and female SD rats	Trimetazid-ine	28 days	Decreased.	Increased.	[(Liu et al., 2018a)]
Male C57BL/6 mice	Fluoxetine	35 days	Decreased.	Increased.	[(Oh et al., 2020)]
Male SD rats	Citalopram	42 days	No differences.	Decreased.	[(Li et al., 2015)]
Male SD rats	Fluoxetine	28 days	Increased.	Decreased.	[(Li et al., 2013)]
Male Wistar rats	Prebiotics (FOS/GOS)	28 days	No changed.	No changed.	[(Li et al., 2019)]
	Probiotics (B.l and L.r)