FIGURE 2-4.

Imaging of the patient in CASE 2-3. Amyloid imaging showed diffuse cortical and subcortical signal consistent with Alzheimer disease (not shown). A, Flortaucipir F 18 positron emission tomography (PET) shows prominent tau binding in the left greater than right posterior temporoparietal area, with milder involvement of the posterior medial frontal gyrus and the posterior cingulate/precuneus region. Flortaucipir F 18 PET images show the standardized uptake value ratio (SUVR) of tau, where warmer colors (yellow, red, and orange) indicate more tau uptake. B, Sagittal volumetric MRI presented in three-dimensional space shows less extensive left greater than right posterior perisylvian atrophy extending into the lateral temporal lobe; warmer colors (yellow, red, and orange) indicate areas of greater gray matter atrophy.