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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Continuum (Minneap Minn). 2022 Jun 1;28(3):676–701. doi: 10.1212/CON.0000000000001082

FIGURE 2-6.

FIGURE 2-6

Imaging of the patient in CASE 2-5. Amyloid imaging showed diffuse cortical and subcortical signal consistent with Alzheimer disease (not shown). A, Flortaucipir F 18 positron emission tomography (PET) showed significant medial and lateral frontal involvement in addition to the classic lateral temporoparietal and medial temporal involvement seen in typical Alzheimer disease. Flortaucipir F 18 PET images show the standardized uptake value ratio (SUVR) of tau, where warmer colors (yellow, red, and orange) indicate more tau uptake. B, Axial fluid-attenuated inversion recovery (FLAIR) MRI shows significant global and frontal lobe atrophy, mild to moderate hippocampal involvement, and minimal white matter changes. C, Axial fludeoxyglucose (FDG)-PET shows frontal, anterior, and middle temporal and bilateral parietal hypometabolism with relative preservation of the posterior cingulate area, which is atypical for Alzheimer disease.