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. 2023 Mar 7;14:1095487. doi: 10.3389/fphar.2023.1095487

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Copyright © 2023 Zeng, Huang, Zhang, Lv, Cheng, Zou, Han, Wang, Gong and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin reduced renal fibrosis in 0.2% adenine diet-fed mice. (A) Serum urea nitrogen (BUN) and creatinine levels in each group. (B) Body weight variation of mice in each grough. (C) HE and Masson staining of renal tissues from each group. (D) Renal HE and Masson scores of each group. Scale bars, 50 μm for all groups. Values are means ± SD. ***p < 0.001 adenine diet group compared with control group; ^## p < 0.01 dapagliflozin treatment group compared with adenine diet group; ^### p < 0.001 dapagliflozin treatment group compared with adenine diet group; p < 0.001 1 mg/kg dapagliflozin treatment group compared with 10 mg/kg dapagliflozin treatment group.