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. 2023 Mar 7;14:1095487. doi: 10.3389/fphar.2023.1095487

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Copyright © 2023 Zeng, Huang, Zhang, Lv, Cheng, Zou, Han, Wang, Gong and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin alleviated inflammation and increased antioxidant proteins in 0.2% adenine diet-fed mice. (A) Real time PCR showing the expression of IL-1β, IL-6, TNF-α, cxcl-1, and mcp-1 in the renal tissue in each group. (B) The activity of SOD and content of GSH in the renal tissue of each group. (C) The content of MDA in the renal tissue of each group. Values are means ± SD. **p < 0.01 adenine diet group compared with the control group; ***p < 0.001 adenine diet group compared with the control group; ^## p < 0.01 dapagliflozin treatment group compared with the adenine diet group; ^### p < 0.001 dapagliflozin treatment group compared with the adenine diet group.