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. 2023 Mar 7;14:1095487. doi: 10.3389/fphar.2023.1095487

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Copyright © 2023 Zeng, Huang, Zhang, Lv, Cheng, Zou, Han, Wang, Gong and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin inhibited the activation of TGF-β1/MAPK pathway in 0.2% adenine diet-fed mice. (A) Real time PCR showing the expression of TGF-β1 in the renal tissue of each group. (B, C) Western blot showing the expression of p-ERK and p-P38 in each group. Values are means ± SD. ***p < 0.001 adenine diet group compared with the control group; ^## p < 0.01 dapagliflozin treatment group compared with the adenine diet group; ^### p < 0.001 dapagliflozin treatment group compared with the adenine diet group.