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NRP predictions categorized by bacterial phyla. (a) Actinobacteria contributed the highest number of A domains. It also has the largest fraction of “unpredictable” A domains, followed by proteobacteria, cyanobacteria, and firmicutes. (b) The top five most frequently used substrate BB in NRP biosynthesis by bacterial phyla. Four BB (Ser, Thr, Val, and Gly) are among the top five most frequently used BB across the four major phyla.
