Table 1.

Cross resistance profile of transfected A673 cells^a

Compound (μM)	A673 EV GI50	A673 B1 GI50	RR	A673 G2 GI50	RR
SN-38	0.0018 ± 001	0.0024 ± .0004	1.3	0.042 ± .00013	23
Doxorubicin	0.010 ± 0.004	0.24 ± 0.075	24	0.017 ± 0.005	1.7
Erastin	2.2 ± 0.42	3.4 ± 1.2	1.5	1.9 ± 0.78	0.86
Erastin2	0.083 ± 0.004	0.17 ± 0.043	2	0.087 ± 0.024	1
Imidazole ketone erastin	0.31 ± 0.25	11.4 ± 5.4	38	0.33 ± 0.24	1.1
Piperazine erastin	1.6 ± 0.416	11 ± 2	6.9	1.4 ± 0.28	0.88
FIN56	0.70 ± 0.43	3.9 ± 2.8	5.6	0.99 ± 0.65	1.4
JKE-1674	1.0 ± 0.20	1.9 ± 0.18	1.9	2.7 ± 0.11	2.7
RSL3	0.055 ± 0.010	0.12 ± 0.008	2.2	0.06 ± 0.003	1.1
Fin02	2.8 ± 1.7	2.8 ± 1.7	1	3.0 ± 1.6	1.1
PACMA31	0.047 ± 0.056	0.07 ± 0.056	1.5	0.045 ± 0.039	0.96
ML-210	0.16 ± 0.031	0.33 ± 0.028	2.1	0.20 ± 0.037	1.2
GPX4 inhibitor 26a	0.077 ± 0.036	0.14 ± 0.050	1.8	0.093 ± 0.020	1.2
ML-162	0.095 ± 0.013	0.20 ± 0.057	2.1	0.12 ± 0.026	1.3
JKE-1716	1.4 ± 0.38	2.5 ± 0.43	1.8	0.81 ± 0.054	0.58

^aResults presented are mean GI₅₀ values +/− SEM. Relative resistance (RR) value was determined by dividing the GI₅₀ value for A673 cells expressing a transporter by the GI₅₀ value for the A673 EV cells. Three independent experiments were performed.