Fig. 10. Pigment accumulation and subsequent neurodegeneration has no effect on behavior.

TH-Cre mice received stereotaxic infusion of AAV5-DIO-hTyr or EYFP control into the LC, and behavior was assessed 6 (a-c) or 10 weeks (d-f) later. hTyr-expressing mice displayed no difference in latency to eat in the novelty-suppressed feeding test (a,d), sleep latency (b,e), or freezing in response to shock-associated context (c,f) at either time point. (N=8–13 per group).