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[Preprint]. 2023 Mar 6:rs.3.rs-2626257. [Version 1] doi: 10.21203/rs.3.rs-2626257/v1

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(A) The respiratory control ratio (RCR is an indicator of the quality of mitochondria. This was determined as outlined in methods. A significant decrease in RCR was seen only in females (p≤0.001), which suggests poorly coupled mitochondria. (B) Complex I-driven mitochondrial respiration (20 mM glutamate and 10 mM malate plus 2mM ADP) shows a significant decrease in females with IBD compared to controls (p≤0.01). No significant difference was observed in males with IBD compared to controls. Male controls were significantly lower compared to females (p≤0.05). (C) Complex II-driven mitochondrial respiration (20 mM succinate plus 2 mM ADP) shows a significant decrease in activity in females with IBD compared to controls (p≤ 0.01). No significant difference was observed in males with IBD compared to controls. Male controls were significantly lower compared to females (p≤ 0.05). (D) LCFA oxidation (0.5 mM Oleate plus 2 mM carnitine) shows a significant decrease in activity in females compared to controls (p≤0.05). No significant difference was observed in males. (E) MCFA oxidation (0.5 mM octanoate) shows a significant shows a significant decrease in activity in females with IBD compared to controls (p ≤ 0.01). No significant difference was observed in males. Male controls were significantly lower compared to females (p≤0.05).