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[Preprint]. 2023 Mar 6:rs.3.rs-2626257. [Version 1] doi: 10.21203/rs.3.rs-2626257/v1

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Individual mitochondrial enzymes activities were measure to determine the location of mitochondrial dysfunction. (A) Complex I activity was significantly decreased in IBD females (p≤ 0.05) compared to controls, but not in males. (B) Complex IV activity showed a significant decrease in IBD females (p≤ 0.05) compared to controls. Again, males showed a lower control activity than females (p≤ 0.05). (C) Complex III activity showed a similar trend with no change in the IBD animals but with the control activity in males being significantly lower than females (p≤ 0.05). (D) Complex II activity showed no significant differences in IBD animals. However, males showed a significantly lower control activity than females (p≤ 0.05). (E). When measuring the antioxidant enzyme activities, IBD males showed a significant decrease in catalase activity (p≤ 0.05) compared to controls.