Figure 8:

ABCG2 substrate specificity of PS with and without Erlotinib in UMUC3 and T24 cells. (A & B)) the uptake of PS 1 and 5 with and without the addition of Gleevec (small molecule inhibitor known to inhibit ABCG2 function) in UMUC3 and T24 cells. Cells were incubated with 500 nm of the Photosensitizers with or without the addition of Gleevec at 1uM concentration. (C-F) The effect of Gleevec on the toxicity of PS 1 and PS 5 at 48 h post incubation (light dose: I J).