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Competitive inhibition of the PD1/PDL1 interaction. (A) Illustration of the PDL1-competitive assay setup used to measure the hairpin 1e binding kinetics to PD1. (B) Progress curve analysis of [PD1•PDL1] formation at varying concentrations of inhibitor 1e in comparison to the full-length antibody pembrolizumab.a
a Experimental data points (mean ± s.d.) from two or four replicates (N ≥ 2) with non-linear fitted progress curves (dashed and dotted lines).
