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. Author manuscript; available in PMC: 2023 Mar 21.
Published in final edited form as: ACS Infect Dis. 2022 Aug 2;8(8):1627–1636. doi: 10.1021/acsinfecdis.2c00229

Table 2.

MIC (μg/mL) (μM) of Penem Derivatives against Mtb H37Rv in Regular 7H9 Medium, 7H9 +25% Human Serum, and 7H9 +25% Mouse Serum

graphic file with name nihms-1883164-t0023.jpg
R:		 MIC-μg/ml (μM) against Mtb H37Rv
Compound Regular 7H9 25% Human Serum 25% Mouse Serum
T405 graphic file with name nihms-1883164-t0024.jpg 0.5 (1.3) 8 (21) 8 (21)
T420 graphic file with name nihms-1883164-t0025.jpg 2 (5.0) 8 (20) 4 (10)
T430 graphic file with name nihms-1883164-t0026.jpg 4 (10) ND 16 (41)
T421 graphic file with name nihms-1883164-t0027.jpg 2 (6.1) 4 (12) 4 (12)
T422 graphic file with name nihms-1883164-t0028.jpg 1 (3.3) 2 (6.6) 2 (6.6)
T432 graphic file with name nihms-1883164-t0029.jpg 4 (10) ND 16 (40)
T431 graphic file with name nihms-1883164-t0030.jpg 4 (12) ND 16 (46)
T426 graphic file with name nihms-1883164-t0031.jpg 0.5 (1.6) 4 (13) 1(3.2)
T425 graphic file with name nihms-1883164-t0032.jpg 0.5 (1.6) 2 (6.3) 1 (3.2)
T427 graphic file with name nihms-1883164-t0033.jpg 1(3.0) 8 (24) 2 (6.1)
T428 graphic file with name nihms-1883164-t0034.jpg 1 1(3.2) 2 (6.3) 2 (6.3)
T429 graphic file with name nihms-1883164-t0035.jpg 0.5 (1.5) 8 (23) 2 (5.8)
Meropenem 8 (21) 16 (42) 8 (21)