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. 2023 Mar 21;25:45. doi: 10.1186/s13075-023-03028-4

Fig. 6.

Fig. 6

TAK-715 inhibited p38MAPK pathway activation and alleviated ECM degradation in ex vivo IVD culture model. A Representative HE and SO/FG staining of ex vivo IVD (scale bar:200 μm); B the histological grades were evaluated (n = 5) C IHC was used to determine the protein expression of p-p38 and Collagen II (upper scale bar:200 μm, lower scale bar:20 μm). D, E The protein expression of p-p38 and collagen II was quantitatively analyzed (n = 3). The data are presented as the mean ± SD (*P < 0.05; **P < 0.01; ***P < 0.001)