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. 2023 Mar 21;16:58. doi: 10.1186/s13048-023-01136-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The number of M2 macrophages was increased by PMSCs in vitro and in vivo. A Cluster analysis by cytokine array showing the difference in paracrine factors of PMSCs after IFNγ-stimulation. B Volcano map. C Model of co-culture of macrophages and PMSCs. D Immunofluorescence analysis of macrophage phenotype, CD206, for M2 macrophages (red) and nuclear staining (blue). E The IHC staining of CD206 in each group rat ovary. Scale bar, 200 μm. F Quantification of macrophage phenotypes. The number of M2-like macrophages increased dramatically in the PMSCs group. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant. Data are means of three independent experiments in each group