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. 2023 Mar 21;23:79. doi: 10.1186/s12876-023-02716-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Study design diagram for the assessment of the intestinotrophic effect of glepaglutide in naive rats and its effects in the INDO-induced small intestinal inflammation model in a co-treatment and post-treatment regimen. A Naive Wistar rats were treated with glepaglutide 400 nmol/kg, glepaglutide 80 nmol/kg, or vehicle (SC, twice daily) for 14 days. B/C Naive Wistar rats were treated with INDO 7 mg/kg (SC, once daily) for 2 consecutive days. Rats with small intestinal inflammation were treated with glepaglutide 400 nmol/kg, control, or INDO control (SC, twice daily) in B co-treatment for 14 days or C post-treatment for 16 days. The dashed rectangles show sacrifice dates. INDO, indomethacin; SC, subcutaneously