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. 2023 Mar 20;14:45. doi: 10.1186/s13287-023-03276-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The transplantation of BM-MSCs overexpressing Numb inhibits the hepatic inflammatory response and liver fibrosis. a Expression of Numb in the livers from a healthy population (n = 10) and patients with PBC (n = 20): Numb immunostaining (× 200) and its positive area. b Experimental flow chart. c Lentivirus-transfected BMSCs (× 100) and Numb protein and mRNA expression levels in BM-MSCs overexpressing Numb (Full-length blot is presented in Additional file 2: Fig. 1). d H&E staining (× 200) and Sirius red collagen staining (× 100). e α-SMA immunostaining (× 200). f Serum levels of biochemical markers. g Hyp content in liver tissue. h α-SMA immunoblotting bands, gray-level integration and mRNA expression (n = 6/per group) (Full-length blot is presented in Additional file 2: Fig. 2). i The mRNA levels of cytokines related to liver fibrosis (n = 6/per group). *P < 0.05; **P < 0.01