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. 2023 Mar 20;14:45. doi: 10.1186/s13287-023-03276-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — BM-MSCs^Numb-OE transplantation inhibits the activation of the Notch signaling pathway in the liver. a Numb, RBP-Jκ and Hes1 immunostaining (× 400). b Protein and mRNA expression levels of Numb, RBP-Jκ, and Hes1 (n = 6/per group) (Full-length blots are presented in Additional file 2: Figs. 3–5); c CK7 and CK19 immunostaining (× 200). d CK7 and CK19 immunoblotting bands, gray-level integration and mRNA expression (n = 6/per group) (Full-length blots are presented in Additional file 2: Figs. 6 and 7). e CK7/EGFP (labeled BM-MSC^OE-EV and BM-MSC^Numb-OE, the same below) immunofluorescence costaining (× 200). f CK19/EGFP immunofluorescence costaining (× 200). g Alb/EGFP immunofluorescence costaining (× 200), and the costaining area ratio of Alb/EGFP. h HNF4α/EGFP immunofluorescence costaining (× 200), and the costaining cells ratio of HNF4α/EGFP. i EGFP/CD90/Alb immunofluorescence costaining (× 400). *P < 0.05; **P < 0.01