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. 2023 Mar 20;14:45. doi: 10.1186/s13287-023-03276-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — BM-MSC^Numb-KD transplantation activates Notch signaling in the livers of CLF rats and induces the differentiation of these cells into BECs. a Numb, RBP-Jκ and Hes1 immunostaining (× 400). b Protein and mRNA expression levels of Numb, RBP-Jκ, and Hes1 (n = 6/per group) (Full-length blots are presented in Additional file 2: Figs. 10–12). c CK7 and CK19 immunostaining (× 200). d Protein and mRNA expression levels of CK7 and CK19 (Full-length blots are presented in Additional file 2: Figs. 13 and 14). e CK7/EGFP (labeling BM-MSC^KD-EV and BM-MSC^Numb-KD) immunofluorescence costaining (× 200), and the costaining area ratio of CK7/EGFP. f CK19/EGFP immunofluorescence costaining (× 200), and the costaining area ratio of CK19/EGFP. *P < 0.05; **P < 0.01