Difference in network assignment of variants across handedness groups. Comparison in the number of variants associated with each network across left and right hemispheres in (A) left-handers and (B) right-handers. Left-handed individuals showed significant differences in visual, frontoparietal, somatomotor lateral, and medial-temporal lobe networks, with more variants in the left hemisphere. Right-handed participants have significantly more right hemisphere variants associated with default mode, cingulo-opercular, and parietal memory networks and more left-hemisphere variants linked to visual, language, somatomotor lateral, and medial-temporal lobe networks. (C) The bar graph shows the average difference across participants in the number of variants associated with each functional network in their left minus their right hemisphere. Interactions between handedness and hemisphere were found for frontoparietal (p = .006) and cingulo-opercular (p = .002) network variants. These comparisons remained significant after FDR correction across all network comparisons. Error bars indicate SEM.